THE DEVELOPMENT AND INVESTIGATION OF TAXIFOLIN-CONTAINING COLLAGEN-ACRYLIC HYDROGELS

The variety of skin diseases determines the importance of numerous works on the creation of new materials, including wound coatings. Significant success has been achieved with hydrogel dressings containing biologically active molecules intended for wounds of varying severity. The aim of this work was to obtain free-radical polymerization of taxifolin-containing hydrogels based on acrylic and collagen as the basis for a wound dressing. The influence of synthesis parameters on the gelation time, sorption kinetics based on a pseudo-second order model and a mathematical model, as well as the drug release of the obtained samples based on the Korsmeyer – Peppas, Higuchi, Bake – Lonsdale and Hixon – Crowell models, respectively. The experimental data about taxifolin release in phosphate buffer solution were obtained.

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