MOLECULAR DOKCING OF SHORT PEPTIDES IN TARGET PROTEINS OF CARDIAC AMYLOIDOSIS
https://doi.org/10.31143/2221-7789-2023-4-110-112
EDN: PYBDDV
Abstract
Cardiac amyloidosis has been shown to be a disease caused by the deposition of insoluble amyloid fibrils. Drugs aimed at treating amyloidosis have a number of disadvantages, so the problem of creating new highly effective drugs is acute. The work carried out molecular modeling and docking of ultrashort peptides into target proteins of cardiac amyloidosis for subsequent peptide synthesis and analysis in animal models of amyloidosis.
About the Authors
P. P. Snetkov
National Research University ITMO
Russian Federation
Russian Federation
M. G. Petukhov
B.P. Konstantinov Petersburg Nuclear Physics Institute
Russian Federation
Russian Federation
S. N. Morozkina
National Research University ITMO
Russian Federation
Russian Federation
M. V. Uspenskaya
National Research University ITMO
Russian Federation
Russian Federation
References
1. Рамеева А.С., Рамеев В.В., Моисеев С.В., Тао П.П., Козловская Л.В. Амилоидная кардиопатия: патоморфология, методы диагностики и лечения // Consilium Medicum. 2018. Т. 20, № 12. С. 15–22.
2. Гудкова А.Я., Полякова А.А., Амелин А.В., Моисеева О.М., Крутиков А.Н., Тишкова В.М., Грозов Р.В., Рыжкова Д.В., Макурова Т.В., Костарева А.А., Семернин Е.Н., Шляхто Е.В. Не VAL30MET-транстиретиновая амилоидная кардиомиопатия. Обзор сведений литературы и клиническое наблюдение // Российский кардиологический журнал. 2018. Т. 2. С. 121–128.
3. Электронный ресурс: https://www.rlsnet.ru/active-substance/diflunizal-548.
4. Snetkov P., Morozkina S., Olekhnovich R., Uspenskaya M. Diflunisal Targeted Delivery Systems: A Review // Materials. 2021. V. 14. P. 6687.
5. Электронный ресурс: https://www.rlsnet.ru/active-substance/tafamidis-3679.
6. Abagyan R., Totrov M. Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins // J. Mol. Biol. 1994. V. 235. P. 983–1002.
7. Khavinson V.K., Linkova N.S., Rudskoy A.I., Petukhov M.G. Feasibility of Transport of 26 Biologi- cally Active Ultrashort Peptides via LAT and PEPT Family Transporters // Biomolecules. 2023. V. 13. P. 552.
Review
For citations:
Snetkov P.P., Petukhov M.G., Morozkina S.N., Uspenskaya M.V. MOLECULAR DOKCING OF SHORT PEPTIDES IN TARGET PROTEINS OF CARDIAC AMYLOIDOSIS. Proceedings of the Kabardino-Balkarian State University. 2023;13(4):110-112. (In Russ.) https://doi.org/10.31143/2221-7789-2023-4-110-112. EDN: PYBDDV
Views:
48
JATS XML
Email this article 