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POLYELECTROLYTE SYSTEMS FOR COMBINED COUNTERACTION TO VIRUSES – THE BIO-NANO-COMPOSITE GENETIC PARASITES

https://doi.org/10.31143/2221-7789-2024-1-77-83

EDN: AFLAZO

Abstract

The principal advantages of macromolecular design of polyelectrolytes in cooperation with multi-vector pharmacophores for scale-adequate protection against viruses are considered, accounting the viral biopolymeric-nanocomposite nature. New possibilities for polyvalent impacts and combination of multilevel mechanisms: 1 – mediated by an immune stimulation (of antibody, interferon production, etc.), 2 – competition with cell receptors for interception the virions, and 3 – direct blocking the genetic parasites reproduction, are demonstrated.

About the Authors

A. V. Serbin
Health Research & Development Foundation; A.V. Topchiev Institute of Petrochemical Synthesis, RAS
Russian Federation


Yu. A. Egorov
A.V. Topchiev Institute of Petrochemical Synthesis, RAS
Russian Federation


O. L. Alikhanova
Health Research & Development Foundation; A.V. Topchiev Institute of Petrochemical Synthesis, RAS
Russian Federation


References

1. Serbin A.V., Karaseva E.N., Tsvetkov V.B., Alikhanova O.L., Rodionov I.L. Hybrid polymeric systems for nano-selective counter intervention in virus life cycle // Macromol. Symp. 2010. V. 296, N 1. P. 466–477.

2. Serbin A.V., Alikhanova O.L. Nanosized Targets of Therapeutic Counter Intervention in the Life Cycle of Viruses // Progress in Chemistry, Technology, and Ecology: Proceedings of the International Scientific and Methodological Conference. Dushanbe: 2023. Pp. 246–248.

3. Belshe B.B., Hay A.J. Drug resistance and mechanism of action amantadine on influenza A viruses //

4. J. Respir. Dis. 1989. V. 10, P. S52–S61.

5. Tandura S.N., Zarubaev V.V., Anfimov P.M., Kiselev O.I. Antifungal Chemopreparation Deitiforin // Antibiotics and Chemotherapy. 2013. Vol. 58, No. 1-2. Pp. 36–48.

6. Antiviral agents for the treatment and chemoprophylaxis of influenza Recommendations of the Advi- sory Committee on Immunization Practices (ACIP) // MMWR 21. 2011. V. 60, N 1. P. 1–26.

7. Stotskaya L.L., Serbin A.V., et al. The efficacy of new adamantane-containing polymers against the influenza virus and their effect on membrane ion transport // Pharm. Chem. J. (Moscow. Russia). 1995. V. 29, N 3. P. 171–174.

8. Burstein M.E., Serbin A.V., Khakhulina T.V., Alymova I.V., Stotskaya L.L., Bogdan O.P., Manukchina E.E., Jdanov V.V., Sharova N.K., Bukrinskaya A.G. Inhibition of HIV-1 replication by newly de- veloped adamantane-containing polyanionic agents // Antiviral Research. 1999. V. 41, N 3. P. 135–144.

9. Serbin A.V. Ways of creating bioselective polymer systems of combined antiviral action: Diss… Dr. chem. sciences. M., 2005. 333 c.

10. Serbin A.V., Veselovsky A.V., Tsvetkov V.B. Research in vitro and in silico interferonogenic analogues of nucleic acids artificially programmed to block the initial stages of HIV-infected cells // Biotechnology. 2012. No. 1. Pp. 72–89.

11. Tsvetkov V.B., Serbin A.V. A Novel View of Modelling interactions between synthetic and biolog- ical polymers via docking // J. Comp.-Aid. Mol. Design. // 2012. V. 26, N 12. P. 1369–1388.

12. Tsvetkov V.B., Serbin A.V. Molecular dynamics modeling the synthetic and biological polymers in- teractions pre-studied via docking // J. Comp.-Aid. Mol. Design. 2014. V. 28, N 6. P. 647–673.

13. Kabanov V.A. From Synthetic Polyelectrolytes to Polymer-Subunit Vaccines // High-Molecular-Weight Compounds A. 2004. Vol. 46, No. 5. Pp. 759–782.

14. Serbin A.V., Karaseva E.N., Dunaeva I.V., et al. Controlled free radical copolymerization of maleic anhydride and divinyl ether in the presence of reversible addition-fragmentation chain-transfer

15. agents // Poly- mer Science, Ser. B. 2011. V. 53, N 3-4. P. 116–124.

16. Bolshchikov B.D., Tsvetkov V.B., Alikhanova O.L., Serbin A.V. How to fight kinetics in complex radical polymerization processes // Macromol. Chem. Phys. 2019. V. 220, N 23. 1900389, P. 1–20.


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For citations:


Serbin A.V., Egorov Yu.A., Alikhanova O.L. POLYELECTROLYTE SYSTEMS FOR COMBINED COUNTERACTION TO VIRUSES – THE BIO-NANO-COMPOSITE GENETIC PARASITES. Proceedings of the Kabardino-Balkarian State University. 2024;14(1):77-83. (In Russ.) https://doi.org/10.31143/2221-7789-2024-1-77-83. EDN: AFLAZO

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